The Science
Technology validated by first principles.
Three converging technology shifts make continuous musculoskeletal biomarker monitoring possible for the first time.
Microneedle ISF Access
Painless, sustained sampling at 1–2mm depth. Continuous analyte capture from interstitial fluid without venipuncture — real-time telemetry, not snapshots.
Electrochemical Biosensors
Clinical-grade sensitivity for proteins and ions in compact, low-power formats. Electrochemical immunosensing, aptamer-based detection, and ion-selective electrodes on a single chip.
Longitudinal AI/ML
Time-series modeling converts continuous biosignals into predictive clinical insights. Gradient Boosting for fracture risk, RNNs for flare prediction, and personalized therapy optimization.
Proprietary Algorithms
The AI forecasting engine.
Continuous data powers predictive models impossible with episodic snapshots.
Time-series CTX-1/P1NP data combined with patient covariates feed a Gradient Boosting Machine that outputs a continuously updated fracture probability and projected BMD trajectory — replacing the static FRAX model.
How It Works
Mechanism of action.
Patch adheres
Painless application to skin surface
→ISF access
Microneedles reach 2mm into interstitial fluid
→Continuous sampling
Analytes captured in real-time
→Equilibration
ISF ↔ blood correlation in 5–30 min
→Live data
Biomarkers streamed to app and clinician
Interstitial fluid equilibrates with blood within 5–30 minutes, enabling near-real-time tracking of bone resorption, formation, mineral balance, and inflammation — without a single blood draw.
Get early access to the future of bone health monitoring.
Join the waitlist and be the first to know when Osteon launches. No spam — we respect your inbox.